Proxemis

Reimagining Research

With years of industry expertise and innovative technology solutions, we’re supporting researchers to deliver successful trials and accelerate the development of ground-breaking treatments. We offer a tailored experience for clinical trial delivery, specialising in primary care.

Challenges facing clinical research teams

Patient identification, recruitment & retention challenges

Lack of therapeutic area specific expertise

Sourcing eligible patients for clinical trials is costly and 80% of clinical trials fail to meet their recruitment target on time. 11% of clinical trial sites fail to recruit a single patient.

Lack of expertise in specific disease areas and health economics can affect the viability of your clinical trial. The human and capital resources required to run your trial can be costly.

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High trial delay & failure rates

Difficulty in modelling implications for clinical practice

Research questions built on unreliable, incomplete or limited data can undermine trial success at the outset. Fixed trial designs don’t allow for flexibility as your trial progresses. Under-representation of different groups within clinical research can impact external validity.

Clinical trials generate large volumes of data that may be difficult to interpret and apply to individual patient cases in real time clinical decision-making. General practice settings often face resource constraints, and implementing complex treatment regimens or interventions studied may not always be feasible.

Unlocking the potential of primary care can enable us to transform clinical research in the UK It’s time to think differently Clinical trial delivery

Rich cradle-to-grave patient data enabling deep phenotyping Reach high-potential subjects at speed and scale through vast GP networks Improve representation through trial participant diversity

Work with the global leading academic primary care centre

“ Primary care is a negligible provider of clinical trial activity, despite the opportunities it provides for delivering population scale trials.” Commercial clinical trials in the UK: the Lord O’Shaughnessy review

90% of healthcare interactions take place in primary care

10% of clinical research takes place in primary care

57% of doctors want to participate in research

Leveraging the world-renowned expertise of the University of Oxford’s Department of Primary Health Care Sciences alongside the reach and capabilities of EMIS, the UK leader in connected healthcare software and systems, we offer customisable end-to-end clinical trial solutions to reimagine research. We aim to make it easier for both patients and clinicians to participate in research, help find better treatments for long-term conditions and deliver research that is truly representative of the UK.

The University of Oxford’s Department of Primary Care Health Sciences is a global leader for academic primary care research with unrivalled expertise.

staff and students 600+ research publications 1100+

developing new evidence and innovations in primary care

involved in shaping projects patient and public representatives 250+

primary care research themes 10

EMIS are the UK leader in connected healthcare software and systems, with technology at the fingertips of clinicians in all major healthcare settings. years 35+ in primary care #1 used by over 4,600 GP practices

used by over 5,500 pharmacies in community pharmacy #1

with 17 million registered users independent patient services app #1

Unrivalled reach and expertise

Real world, data-driven feasibility testing and statistical design

Recruit high potential candidates at speed and scale

Appropriate representation ensuring external validity

Experience and expertise in chronic disease

Implement research findings back into healthcare systems

Expertise you can Trust

Data • Long history of safely and securely managing clinical data for the NHS, including over 40 million longitudinal patient records. • In partnership with healthcare providers, rapidly connect you to data at source, enabling GDPR compliant, secure data analysis. • Data applications integrated into clinical systems can be used post launch to promote take up and track safety and efficacy of interventions. Delivery • Research designed and led by internationally renowned scientists from the world’s leading academic centre of primary care. • Dedicated in-house Primary Care Clinical Trials Unit. • Academic publications, health economics cases and statistical analysis prepared by experts in each field.

No matter what you need for your clinical trial, we’ve got you covered. We’ll work alongside you to design a tailored approach that meets your needs. Our solutions

• • • • • • •

Statistical design and analysis Patient recruitment solutions

​Investigator and site management services

Medical writing and publishing Decentralised clinical trials

Dedicated site services

Clinical implementation solutions

Statistical design & analysis All the essential elements you need to initiate a successful clinical trial. • All regulatory authority applications • Data collection and reporting • Data capture and statistical analysis Patient recruitment solutions Leverage EMIS point-of-care systems to source quality candidates at speed and scale. • Participant recruitment via vast GP network • High potential candidates identified at pace and scale using patient health data • Diverse participant base for representative research Investigator & site management services Ensure the smooth running of your clinical trial and take care of any regulatory compliance monitoring. • Trial documentation • Clinical study support services • End-to-end support of any serious adverse events

Our solutions:

Medical writing & publishing Writing up and publishing your clinical trial results. • Development of patient facing documents • Creation of clinical study reports • Writing and publishing of results in appropriate journals Decentralised clinical trials Leverage new approaches and technologies to make clinical research more accessible. • Facilitation of remote or virtual patient consultations • Support with home visits • Incorporation of wearable tech solutions Dedicated sites service Manage recruitment and trial conduct activities for dedicated sites within your clinical trial. • Identification and training of GP practices and/or community pharmacy settings to become research sites • Embedding research into local communities

We’re committed to driving the real-world impact of your vital research. As well as supporting the end-to-end delivery of your clinical trial, we also offer services to support the implementation and adoption of novel treatments developed through clinical research, and to help you to share your findings with patients and healthcare professionals. Clinical implementation solutions

Clinical system alerts Leveraging market-leading clinical systems to deploy alerts that guide decision-making at the point of care and optimise care delivery. Communicating to patients Get your research in front of over 1 million patients who have opted-in to receive tailored information through our market leading app. Case finding Identify cohorts of at-risk patients from within primary care data for proactive healthcare interventions. Educational content Design bespoke educational content for healthcare professionals to share your research findings with the healthcare community.

Let’s work together We’d love the opportunity to demonstrate in more detail how Proxemis is reimagining research in the UK.

Alex Eavis Director

John McCormack Director

Lucy Mackillop Director

Bernard Taylor Director

Linda Naughton Director

Richard Hobbs Director

Please get in touch via the email below to find out howwe can support your goals. Website: www.proxemis.com Email: info@proxemis.com